Adipotide (FTPP) 5mg

1. What is Adipotide?

Adipotide (also known as FTPP) is a synthetic peptide developed to target and eliminate white adipose tissue through a novel mechanism involving apoptosis of fat-specific blood vessels. Originally investigated for its potential in obesity treatment, Adipotide binds to specific receptors present on the blood vessels supplying white fat, leading to vascular shutdown and fat cell death.

2.Adipotide Structure

Sequence:Cys-Lys-Gly-Gly-Arg-Ala-Lys-Asp-Cys-Gly-Gly-(Lys-Leu-Ala-Lys-Leu-Ala-Lys）₂ Molecular Formula:C₁₁₁H₂₀₆N₃₆O₂₈S₂

Molecular Weight: 2557.2 g/mol

3.Adipotide Research

Adipotide: Targeted Fat Loss Peptide

Adipotide is a proapoptotic peptide designed to target and destroy adipose tissue vasculature by specifically binding to prohibitin receptors. This targeted action leads to the apoptosis of fat cells, resulting in rapid fat loss. In clinical studies on obese rhesus monkeys, Adipotide caused a significant reduction in visceral fat, with results showing a 11% weight loss and 27–39% visceral fat reduction without impacting lean mass.

Targeted Fat Reduction: Adipotide works by targeting blood vessels in adipose tissue, making it different from traditional weight loss methods that affect the entire body (https://pubmed.ncbi.nlm.nih.gov/24002499/).

Fat Loss Mechanism: The peptide utilizes the D(KLAKLAK)₂ sequence to destroy the mitochondria of adipose endothelial cells, initiating fat cell death (https://pubmed.ncbi.nlm.nih.gov/24002499/).

【1】 Adipotide and Fat Loss

In the preclinical trials, rhesus monkeys treated with Adipotide experienced a rapid decrease in body weight and a significant reduction in visceral fat. The treatment did not affect lean muscle mass, but there was a significant improvement in insulin resistance markers, suggesting that Adipotide may not only support fat loss but also offer metabolic benefits.

Key Observations:

The treated monkeys had a decrease in food consumption, likely caused by changes in metabolism (https://pubmed.ncbi.nlm.nih.gov/24002499/).

BMI reduction was shown, demonstrating that Adipotide helps reduce fat without compromising muscle mass.

Insulin sensitivity was markedly improved after Adipotide treatment, further supporting its role in managing metabolic health.

【2】 Adipotide and Insulin Sensitivity

Adipotide has shown promising results in improving insulin sensitivity. In rodent studies, the peptide reduced insulin resistance without significant weight loss, highlighting that it can improve glucose metabolism while also promoting fat loss. This suggests that Adipotide could play a role in treating metabolic conditions like pre-diabetes and type 2 diabetes (https://pubmed.ncbi.nlm.nih.gov/24002499/).

【3】Adipotide and Appetite Control

Interestingly, studies have shown that Adipotide treatment resulted in a decrease in food consumption in the treated animals. This reduction in appetite is believed to be due to the effects of Adipotide on the hypothalamus, which is the brain region responsible for regulating hunger and satiety. This suggests that Adipotide may help control food intake and improve dietary compliance without needing to enforce calorie restriction.

Key Findings:

Treated monkeys showed lower food intake, a sign of Adipotide’s role in appetite suppression and hunger regulation (https://pubmed.ncbi.nlm.nih.gov/24002499/).

The change in eating behavior suggests that Adipotide may offer a non-invasive approach to appetite regulation for weight management.

【4】 Clinical Trials and Ongoing Research

Adipotide is currently undergoing Phase I clinical trials to evaluate its safety and efficacy in humans. These trials are focused on its ability to promote fat loss, improve insulin sensitivity, and assess its effects on visceral fat in humans. Results from animal studies have been promising, and researchers are excited about the potential applications of this peptide for obesity treatment and metabolic health (https://clinicaltrials.gov/study/NCT01262664?utm_source=chatgpt.com).

✅ Why Choose Adipotide?

Precision fat removal targeting the root cause—blood vessels of fat cells.

Rapid and significant fat/fat-weight loss confirmed in primates.

Metabolic health boost via improved insulin sensitivity.

First-in-class mechanism offering a new option for obesity research.

4. Future Adipotide Research

The primary area of adipotide research is in fat loss and diabetes. The peptide targets specific cells in the blood vessels that supply fat tissue, causing those blood vessels to die and, as a result, causing the fat cells they supply to die. Adipotide is an anti-

angiogenic peptide, which means it targets blood vessels. Anti-angiogenic molecules are of keen interest right now in the treatment of cancer. There is limited, but promising research, on the role of adipotide in cancer.

Adipotide exhibits minimal side effects, low oral and excellent subcutaneous

bioavailability in mice. Per kg dosage in mice does not scale to humans. Adipotide for sale at Peptide Sciences is limited to educational and scientific research only, not for human consumption. Only buy Adipotide if you are a licensed researcher.

5. Application Area

Adipotide is actively studied in the following fields:

• 🧪 Experimental fat loss and obesity research
• 🔬 Metabolic syndrome modeling and insulin resistance studies
• 🧬 Vascular-targeted drug development
• 🩺 Future anti-obesity pharmacology pipelines

Due to its mechanism that does not rely on CNS interaction, it’s especially relevant in non-behavioral weight loss protocols.

ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATONAL AND EDUCATIONAL PURPOSES ONLY.

The products offered on this website are furnished for in-vitro studies only. In-vitro studies(Latin: in glass) are performed outside of the body. These products are not medicines or drugs and have not been approved by the FDA to prevent, treat or cure any medical condition, ailment or disease. Bodily introduction of any kind into humans or animals is strictly forbidden by law.