CJC-1295 2mg

1. What is CJC-1295 without DAC?

CJC-1295 without DAC is a synthetic growth hormone-releasing hormone (GHRH) analog composed of 30 amino acids. It is designed to stimulate the natural release of growth hormone (GH) and insulin-like growth factor 1 (IGF-1) from the pituitary gland. Unlike the DAC (Drug Affinity Complex) version, CJC-1295 without DAC has a shorter half-life and is commonly used in combination with other peptides like GHRP-2 or GHRP-6 for pulsatile GH release.

2. CJC-1295 without DAC Structure

Sequence:Tyr-D-Ala-Asp-Ala-lle-Phe-Thr-GIn-Ser-Tyr-Arg-Lys-Val-Leu-Ala-GIn-Leu-Ser-Ala-Arg-Lys-Leu-Leu-GIn-Asp-lle-Leu-Ser-Arg-NH2

Molecular formula:C152H252N44O42

Molar Mass: 3367.9g/mol

Synonyms: Mod GRF 1-29, CJC-1295 no DAC

3. CJC-1295 without DAC Research

CJC-1295 without DAC, also known as Modified GRF (1-29), is a synthetic peptide designed to stimulate the natural release of growth hormone (GH) from the anterior pituitary gland. Unlike its counterpart with DAC (Drug Affinity Complex), this version is short-acting, offering pulsatile GH release that closely resembles the body’s natural rhythm. This makes it ideal for users seeking a physiological and controlled elevation of GH without sustained spikes or hormonal saturation.

【1】How It Works

CJC-1295 without DAC functions as a tetra-substituted analog of GHRH (1-29). The structural modifications increase the peptide’s resistance to enzymatic degradation, enabling it to remain active longer than native GHRH, yet still brief enough to avoid continuous GH stimulation.

Once administered, it binds to GHRH receptors in the pituitary, triggering the release of growth hormone【https://pmc.ncbi.nlm.nih.gov/articles/PMC8238899/】 in a natural, wave-like pattern. This pulsatile stimulation supports tissue repair, lean muscle growth, and fat metabolism—while minimizing side effects associated with long-acting or exogenous GH.【https://www.ncbi.nlm.nih.gov/books/NBK538289/】

【2】 Key Benefits and Clinical Applications

CJC-1295 without DAC has gained popularity due to its physiological safety profile and performance-enhancing potential. Documented benefits include:

🔹 Increase in IGF-1 levels: IGF-1 (Insulin-like Growth Factor 1) is responsible for cell growth, repair, and metabolic regulation.

🔹 Improved body composition: Users report enhanced fat loss and muscle density over time.

🔹 Enhanced sleep quality: Growth hormone secretion is linked to deep sleep stages, promoting better recovery.

🔹 Support for joint and tissue health: Through collagen production and connective tissue reinforcement.

CJC-1295 without DAC is often used with Ipamorelin【https://pubmed.ncbi.nlm.nih.gov/14696907/】 to create a synergistic effect, stimulating GH release via different mechanisms for maximized anabolic response and minimized cortisol or prolactin elevation.

【3】How It Compares to Other Peptides

The short half-life of CJC-1295 without DAC allows daily dosing timed with circadian GH peaks—often before sleep—for enhanced outcomes.

✅ Why Consider CJC-1295 Without DAC?

🔁 Supports natural GH cycles without long-term suppression

💡 Pairs effectively with Ipamorelin for full-spectrum growth hormone release

🏋️‍♂️ Promotes muscle gain and fat reduction

🛌 Improves recovery and sleep quality

🧬 Enhances tissue repair and IGF-1 signaling

✅ Safe and well-tolerated in healthy adults

⏱️ Short-acting: Allows flexible dosing and reduced side effect risk

4. Future CJC-1295 without DAC Research

As interest in peptide-based therapies continues to grow, CJC-1295 without DAC has emerged as a subject of renewed scientific interest—especially in the context of short-acting growth hormone secretagogues (GHS) that offer better timing control and less prolonged stimulation than their DAC-linked counterparts. Future research is expected to focus on three major domains: dose-response optimization, clinical efficacy in targeted therapeutic areas, and comparative studies with DAC and other GH-releasing peptides (GHRPs).

【1】Optimizing Pulsatile GH Stimulation

Unlike CJC-1295 with DAC, which results in extended GH elevation, the DAC-free version allows for pulsatile GH release, mimicking the body’s natural secretion rhythm. This characteristic makes it especially interesting for future studies in athletic recovery, age-related GH decline, and short-term metabolic interventions.
According to a study published in Clinical Endocrinology,“The pulsatile secretion of growth hormone may be more physiologically favorable than sustained elevation, especially in preserving receptor sensitivity and avoiding desensitization.”【https://pubmed.ncbi.nlm.nih.gov/18269284/】

Researchers are expected to explore how timing, dose, and co-administration with other peptides like Ipamorelin or GHRP-6 affect the amplitude and frequency of GH pulses. These studies will help clarify whether short-acting CJC-1295 may offer improved fat loss, muscle repair, or sleep quality with fewer endocrine disruptions compared to long-acting variants.

【2】Therapeutic Potential in Aging, Sarcopenia, and Neuroendocrine Balance

Future clinical research may also investigate CJC-1295 without DAC as a potential therapy in sarcopenia (age-related muscle loss), hypopituitarism, and neuroendocrine aging syndromes. Its more transient GH pulse makes it a candidate for restoring natural cycles without overloading the IGF-1 axis, which has been associated with potential risks in cancer-prone individuals.
A research overview published in Frontiers in Endocrinology stated:“The episodic stimulation of GH release without chronic elevation of IGF-1 may reduce long-term oncogenic risk and improve endocrine balance in aging individuals.”

Additionally, research into sleep-regulated GH peaks and circadian timing is likely to increase, especially given that DAC-free CJC-1295 is commonly used at night to coincide with natural pituitary activity. Combined with lifestyle or exercise-based interventions, future studies may explore how this peptide can be integrated into biohacking protocols, age management, or even cognitive enhancement regimes.

【3】Comparative and Synergistic Research

With the rise of customized peptide protocols, future trials will likely compare CJC-1295 without DAC directly against other GH secretagogues such as Tesamorelin, Sermorelin, or MK-677, focusing on efficacy, safety, half-life, and patient-reported outcomes.
There’s also growing interest in synergistic stacking—using this peptide in conjunction with GH-releasing hexapeptides (like GHRP-2/6), Ipamorelin, or Thymosin Beta-4, to achieve enhanced tissue repair, fat metabolism, and recovery without systemic GH saturation.

Finally, bioavailability, injection frequency, and alternative delivery systems (e.g., transdermal, sublingual) may be areas of innovation. As the market matures, clinicians and peptide developers will seek to balance clinical precision with patient convenience, potentially improving adherence and outcomes.

5. Application Area

CJC-1295 without DAC is widely researched for its ability to stimulate natural growth hormone (GH) release in a pulsatile, physiological manner. Unlike its DAC-bound counterpart, it mimics the body’s natural GH rhythm, making it highly relevant in:

• 🧪Laboratory studieson GH-releasing hormone analogs and endocrine regulation
• ⏳ Anti-aging research, targeting muscle preservation, fat metabolism, and recovery
• 🏋️Sports performance and recovery, particularly in short-term GH pulse enhancement protocols
• 🧠 Neuroendocrine and sleep research, investigating GH-related cognitive and circadian functions

Its short half-life allows for controlled GH stimulation without sustained elevation of hormone levels, making it a preferred compound in intermittent-release peptide studies.

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The products offered on this website are furnished for in-vitro studies only. In-vitro studies(Latin: in glass) are performed outside of the body. These products are not medicines or drugs and have not been approved by the FDA to prevent, treat or cure any medical condition, ailment or disease. Bodily introduction of any kind into humans or animals is strictly forbidden by law.