GHRP-2 5mg

1. What is GHRP-2?

GHRP-2 (Growth Hormone Releasing Peptide-2) is a synthetic hexapeptide that stimulates the secretion of growth hormone (GH) by acting on the ghrelin receptor (GHS-R1a) in the pituitary and hypothalamus. It is part of the GHRP family, which includes other peptides like GHRP-6 and Ipamorelin. GHRP-2 is primarily used in research settings for its potential to promote GH release, support lean muscle growth, and aid recovery.

2. GHRP-2 Structure

【pictures linking，https://pubchem.ncbi.nlm.nih.gov/compound/6918245】

Sequence: D-Ala-D-2Nal-Ala-Trp-D-Phe-Lys

Molecular Formula: C45H55N9O6

Molecular Weight: 817.9749 g/mol
PubChem CID: 6918245

CAS Number: 158861-67-7

Code Names: KP-102,GPA-748,WAY-GPA-748

3. GHRP-2 Research

GHRP-2 (Growth Hormone Releasing Peptide-2) is a synthetic hexapeptide (sequence: D-Ala-D-2-Nal-Ala-Trp-D-Phe-Lys-NH₂) that belongs to the family of ghrelin mimetics or secretagogues, designed to stimulate endogenous growth hormone (GH) release via direct action on the pituitary gland and hypothalamus.

Unlike GHRH (growth hormone-releasing hormone), which acts only on GHRH receptors, GHRP-2 activates the GHSR-1a receptor (ghrelin receptor), making it synergistic with GHRH and effective even in aging or GH-deficient individuals.

【1】Mechanism of Action

Pituitary Stimulation: Binds to GHSR-1a on anterior pituitary somatotrophs, promoting GH pulse release, often increasing GH levels 5- to 15-fold within 30 minutes 【https://pubmed.ncbi.nlm.nih.gov/8675588/】.

Hypothalamic Activation: Triggers arcuate nucleus neurons to enhance GH-releasing hormone output and reduce somatostatin (GH-inhibiting hormone).

Ghrelin-Like Effects: Mimics endogenous ghrelin, promoting hunger, gastric motility, and positive energy balance.

【2】 Clinical & Biological Effects

GH & IGF-1 Elevation: Boosts serum GH and insulin-like growth factor 1 (IGF-1), enhancing anabolic recovery and cellular regeneration.

Fat Loss & Lean Mass: Promotes lipolysis while preserving lean mass, especially in hypogonadal, elderly, or cachectic populations (Journal of Clinical Endocrinology).

Immune & Recovery Support: GH is known to modulate immune activity and collagen synthesis; GHRP-2 may indirectly support wound healing and anti-inflammation.

【3】Expert Commentary

Nature Reviews Endocrinology (2020): “GHSR-1a agonists like GHRP-2 offer the advantage of pituitary-independent GH stimulation, bypassing age-related hypothalamic inhibition.”

Dr. Thierry Hertoghe: “GHRP-2 may be the most reliable and stable GH releaser, effective even in patients with reduced pituitary responsiveness.”

✅ Why Consider GHRP-2?

💪 Potent GH secretagogue, works at both pituitary and hypothalamic levels

🧬 Elevates IGF-1, driving cellular repair, metabolism, and lean tissue recovery

🔄 Mimics ghrelin, improving appetite and energy utilization in undernourished states

🛌 Supports recovery, sleep quality, and age-related regenerative decline

🧠 Low desensitization risk with cyclic or combined use protocols

🧪 Safe, well-studied, and synergistic with GHRH, CJC-1295, or IGF therapies

4. Future GHRP-2 Research

A. Combination Therapies for GH Deficiency & Aging

Trials are underway to combine GHRP-2 with CJC-1295, leveraging GHRH + GHSR synergy for enhanced GH pulsatility.

Research suggests combining GHRP-2 with testosterone replacement, thyroid support, or metformin may yield optimal metabolic restoration in aging males (NIH Study Protocols).

B. Appetite & Cachexia Management

GHRP-2 is being investigated as a therapeutic appetite stimulant in:

Cancer cachexia

Anorexia nervosa

HIV-related wasting syndromes

Future dosing protocols aim to balance anabolic and orexigenic effects for patients with chronic undernutrition.

C. Pediatric Endocrinology

Trials in GH-deficient children explore GHRP-2 as a safer alternative to exogenous GH, with more physiological pulsatility and lower tumor-promoting risk.

D. Cardiometabolic & Cognitive Health

Animal studies show GHRP-2 may improve cardiac remodeling post-MI, and protect against oxidative stress in vascular tissues.

Investigation into cognitive benefits (via IGF-1–linked neurogenesis) in models of early dementia or traumatic brain injury is ongoing.

E. Delivery Technology & Dosing Advances

Oral, sublingual, and intranasal formulations under study to improve ease of use and adherence.

GH “reboot” protocols using cyclical GHRP-2 for hypothalamic-pituitary axis recalibration in long-term steroid or GH abuse recovery patients.

5. Application Area

🧬 Hormonal Optimization & Anti-Aging

Used in age-management protocols, longevity clinics, and biohacking stacks

Enhances energy, libido, sleep, and recovery

💪 Muscle Preservation & Fat Loss

Popular in post-cycle therapy (PCT) for anabolic steroid users

Improves body composition in elderly or hormone-suppressed patients
【https://pubmed.ncbi.nlm.nih.gov/11397840/】

🧠 Cognitive & Neurological Regeneration

IGF-1 upregulation improves brain plasticity, sleep depth, and mood stabilization

Considered in TBI recovery and neuroendocrine fatigue

🩺 Clinical Endocrinology

Investigated in:

Adult GH deficiency

HIV/AIDS wasting

Functional pituitary suppression (e.g., after opioids, stress)

✅ Summary

GHRP-2 is a powerful GH-releasing peptide with diverse clinical and wellness benefits:

✔️ Stimulates both GH and IGF-1 naturally

✔️ Enhances anabolism, lipid metabolism, tissue recovery

✔️ Safe, non-immunogenic, with decades of human study

✔️ Versatile applications: aging, wasting, athletics, cognition, hormonal recovery

✔️ Works synergistically with CJC-1295, Follistatin, or IGF-based therapies

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The products offered on this website are furnished for in-vitro studies only. In-vitro studies(Latin: in glass) are performed outside of the body. These products are not medicines or drugs and have not been approved by the FDA to prevent, treat or cure any medical condition, ailment or disease. Bodily introduction of any kind into humans or animals is strictly forbidden by law.