Gonadorelin Acetate 2mg

1. What is Gonadorelin Acetate?

Gonadorelin Acetate is a synthetic version of gonadotropin-releasing hormone (GnRH), which is responsible for regulating the release of gonadotropins—luteinizing hormone (LH) and follicle-stimulating hormone (FSH)—from the anterior pituitary gland. It is used therapeutically to treat various reproductive and hormonal disorders, including infertility, polycystic ovary syndrome (PCOS), and delayed puberty. Gonadorelin Acetate works by stimulating the hypothalamic-pituitary-gonadal (HPG) axis, promoting the natural release of gonadotropins.

2. Gonadorelin Acetate Structure

【pictures linking，https://pubchem.ncbi.nlm.nih.gov/compound/638793】

Sequence: Pyr-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly

Molecular Formula:C55H75N17O13·C2H4O2

Molecular Weight:1182.3 g/mol

PubChem CID: 638793

CAS Number:34973-08-5

Synonyms: Growth Hormone Releasing Factor, Somatocrinin, Somatoliberin

3. Gonadorelin Acetate Research

Gonadorelin Acetate is a synthetic form of gonadotropin-releasing hormone (GnRH), a decapeptide that stimulates the anterior pituitary gland to release luteinizing hormone (LH) and follicle-stimulating hormone (FSH). These downstream hormones regulate the hypothalamic-pituitary-gonadal (HPG) axis, making Gonadorelin a foundational peptide in fertility medicine, hormone restoration, and endocrine diagnostics.

It is bioidentical to natural human GnRH and is commonly used for diagnostic testing, hypogonadism treatment, and even puberty induction.

【1】Mechanism of Action

Binds to GnRH receptors on anterior pituitary gonadotrophs, triggering a pulsatile release of LH and FSH, which in turn stimulate testosterone, estradiol, and spermatogenesis or folliculogenesis depending on sex.

In pulsed dosing, Gonadorelin mimics natural hypothalamic function.

In continuous high-dose exposure, it desensitizes GnRH receptors, reducing LH/FSH—useful in hormone-sensitive cancers.

【2】 Clinical Research Highlights

Used to evaluate pituitary reserve and delayed puberty in adolescents (NIH Protocol).

Approved for hypogonadotropic hypogonadism and secondary amenorrhea in both sexes.

Enhances testosterone and sperm production in subfertile men with low LH levels 【https://pubmed.ncbi.nlm.nih.gov/3104967/】.

【3】Expert Insights

Journal of Clinical Endocrinology & Metabolism: “Gonadorelin remains the gold standard for assessing GnRH responsiveness in suspected pituitary or hypothalamic dysfunction.”

Reproductive endocrinologists note its “predictable pharmacokinetics, short half-life, and excellent pituitary selectivity” as major clinical advantages.

✅ Why Consider Gonadorelin Acetate?

🧬 Directly stimulates natural LH/FSH production

💡 Ideal for diagnosis or reversal of HPG axis suppression

💪 Supports testosterone production and fertility in men

🩺 Beneficial in female reproductive restoration, PCOS or amenorrhea

🚫 Alternative to exogenous hormone therapy, lowers side effects risk

🧠 Non-immunogenic, short-acting, and highly predictable

4. Future Gonadorelin Acetate Research

A. Male Hormone Restoration & Post-Steroid Recovery

Gonadorelin is being increasingly used in post-anabolic steroid recovery protocols to re-initiate natural LH/FSH/testosterone axis function.

May replace hCG, which can desensitize Leydig cells with long-term use.

Combined use with Clomiphene or Enclomiphene under investigation for full axis restoration.

B. Female Reproductive Health & Ovulation Support

Future studies are exploring microdose pulsatile delivery via programmable infusion pumps to mimic natural GnRH rhythm for treating:

Anovulatory infertility

PCOS-related ovulatory dysfunction

Functional hypothalamic amenorrhea (FHA)

Could offer more physiological results than exogenous LH/FSH injections.

C. Oncology & Hormone Suppression Therapy

High-dose Gonadorelin is being evaluated as an alternative to GnRH agonists (like Leuprolide) for prostate and breast cancer, with faster reversibility and less bone density loss.

Promising option in GnRH antagonist-sensitive tumors, offering shorter receptor desensitization window and lower cardiovascular risks.

D. Novel Delivery Technologies

Intranasal and sublingual spray formulations under development to replace IV/subQ delivery while preserving pulsatility.

Biochip or wearable infusion devices being tested for fertility patients.

5. Application Area

🧪 Endocrine Diagnostics

Used to test HPG axis integrity in:

Delayed puberty

Hypogonadism

Amenorrhea
→ GnRH stimulation test – NIH【https://www.ncbi.nlm.nih.gov/books/NBK538254/】

🔁 Hormone Replacement & Fertility

Men: Improves LH → testosterone → sperm production

Women: Re-establishes FSH/LH → ovulation → estradiol normalization
→ GnRH in fertility – Reproductive Biology Update

【https://pubmed.ncbi.nlm.nih.gov/21890336/】

🔬 Post-Cycle Therapy (PCT)

Used by clinicians and longevity doctors to restart testosterone production following anabolic steroid use.

🧬 Cancer Hormone Suppression

High-dose protocols under trial for:

Prostate cancer

Endometrial or breast cancer

With faster hormonal recovery than traditional agonists
→ Gonadorelin vs GnRH agonists

【https://pubmed.ncbi.nlm.nih.gov/21111083/】

🤖 Pulsatile Reproduction Technologies

Infusion pump use in infertility clinics to replicate circadian GnRH pulsatility and improve ovulation rates without hyperstimulation

✅ Summary

Gonadorelin Acetate is a potent, precise, and flexible regulator of reproductive hormones:

✔️ Directly activates natural LH and FSH release

✔️ Used in diagnostics, fertility, post-steroid recovery, and cancer therapy

✔️ Offers reversible, short-acting hormone control

✔️ Highly adaptable via infusion pumps, injections, or future nasal delivery

✔️ Validated across pediatrics, reproductive medicine, and oncology

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The products offered on this website are furnished for in-vitro studies only. In-vitro studies(Latin: in glass) are performed outside of the body. These products are not medicines or drugs and have not been approved by the FDA to prevent, treat or cure any medical condition, ailment or disease. Bodily introduction of any kind into humans or animals is strictly forbidden by law.