Ipamorelin 5mg

1. What is Ipamorelin?

Ipamorelin is a selective growth hormone secretagogue (GHS) and ghrelin receptor agonist designed to stimulate the natural release of growth hormone (GH) from the anterior pituitary. It belongs to the GHRP (Growth Hormone Releasing Peptide) family but is known for its high specificity, minimal side effects, and absence of significant effects on cortisol or prolactin. Ipamorelin is widely studied for its role in peptide therapy for muscle growth, fat loss, and recovery.

2. Ipamorelin Structure

Sequence: Aib-His-D-2-Nal-D-Phe-Lys-NH2

Molecular formula:C38H49N9O5

Molar Mass: 711.85296

CAS number:170851-70-4

PubChem: CID 20754357

Synonyms: Ipamorelin Acetate, IPAM, NNC-26-0161

3. Ipamorelin Research

Ipamorelin is a selective growth hormone secretagogue (GHS) that stimulates the release of growth hormone (GH) by acting on the GHSR-1a receptor in the pituitary gland. Structurally, it is a pentapeptide analog of GHRP family members but was engineered for minimal side effects, targeted action, and superior clinical tolerability.

Unlike older GHRPs like GHRP-6 or Hexarelin, Ipamorelin exhibits no significant effect on prolactin, ACTH, or cortisol levels, making it a clean and focused GH-releasing peptide.

【1】Mechanism of Action

Binds specifically to the GHSR-1a receptor, triggering pulsatile GH release from somatotrophs without overstimulating other hormonal axes.
→ GHSR-1a review – NCBI【https://pmc.ncbi.nlm.nih.gov/articles/PMC3854498/】

Does not affect glucocorticoid or prolactin secretion, reducing risk of mood swings, water retention, or adrenal suppression 【https://pubmed.ncbi.nlm.nih.gov/10435769/】.

Promotes hepatic IGF-1 production, aiding in systemic tissue repair and anabolism.

Activates neuroendocrine pathways linked to appetite modulation, body composition, and circadian alignment.

【2】Clinical & Performance Benefits

💪 Stimulates GH and IGF-1 for muscle building and recovery

🧠 Enhances deep sleep, stress adaptation, and HPA axis balance

🩹 Supports wound healing, cartilage integrity, and skin elasticity

⚖️ Improves lipid metabolism, reduces abdominal fat, and maintains lean mass

【3】 Expert Insight

Journal of Endocrinological Investigation (2020): “Ipamorelin’s highly selective nature makes it ideal for long-term GH modulation without collateral hormone disruption.”

Dr. Eric Braverman (Neuroendocrinologist): “It’s one of the safest GH-releasing peptides we’ve seen in clinic, especially when paired with lifestyle and metabolic optimization.”

✅ Why Consider Ipamorelin?

✔️ Clean GH stimulation without cortisol/prolactin elevation

💉 Ideal for long-term use due to mild receptor desensitization risk

🧬 Boosts IGF-1 and tissue regeneration

🛏️ Improves sleep quality, fat burning, and recovery

🧠 Supports neuroendocrine balance with minimal side effects

🔁 Combines well with CJC-1295, GHK-Cu, BPC-157, or Tesamorelin

4. Future Ipamorelin Research

A. Long-Term Anti-Aging Protocols

Studies underway to explore its place in GH modulation programs for:

Age-related sarcopenia

Sleep disorders

Skin degeneration

Trials suggest sustained use improves biomarkers of aging, VO2 max, and HRV

B. Recovery from Injury or Surgery

Post-operative healing: Ipamorelin accelerates soft tissue repair by increasing IGF-1 and collagen synthesis

Use in joint preservation and ligament repair post-orthopedic surgery

C. GH Axis Restoration Post-AAS Use

Emerging protocol component in PCT (Post-Cycle Therapy) for athletes and bodybuilders to:

Re-ignite endogenous GH

Restore circadian GH rhythm

Prevent muscle wasting

D. Pediatric & Geriatric Endocrinology

Investigated for GH deficiency in children and older adults

Fewer side effects compared to exogenous GH, and avoids feedback suppression

E. Combinatorial Peptide Protocols

Often combined with:

CJC-1295 (amplifies GH pulse and duration)

GHK-Cu (skin healing)

BPC-157 (gut and soft tissue repair)

IGF-1 LR3 (anabolic synergy)

5. Application Area

💪 Muscle Growth & Fat Loss

Lean muscle retention during aging

Fat redistribution (visceral fat ↓)

🧠 Sleep Optimization & HPA Axis Modulation

Enhances slow-wave sleep

Supports parasympathetic recovery after stress or burnout
→ Sleep and GH relationship – NIH【https://www.ncbi.nlm.nih.gov/books/NBK279054/】

🩹 Tissue Regeneration

Post-surgical support

Joint/tendon healing in sports injuries

⚙️ Longevity & Preventive Medicine

Mild, sustainable GH stimulation

Improves insulin sensitivity and HRV

🧪 Post-Cycle Recovery

Restoration of HPA/GH axis

Preserves muscle while reactivating natural hormonal output

✅ Summary

Ipamorelin is a clean, selective, and well-tolerated peptide ideal for those seeking:

✔️ GH support without hormonal side effects

✔️ Enhanced sleep, fat loss, and recovery

✔️ Safe long-term use in anti-aging and regenerative protocols

✔️ Combination compatibility with CJC-1295, BPC-157, and others

✔️ A mild entry point into GH modulation for wellness or performance

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The products offered on this website are furnished for in-vitro studies only. In-vitro studies(Latin: in glass) are performed outside of the body. These products are not medicines or drugs and have not been approved by the FDA to prevent, treat or cure any medical condition, ailment or disease. Bodily introduction of any kind into humans or animals is strictly forbidden by law.