Kisspeptin-10 5mg

1. What is Kisspeptin-10?

Kisspeptin-10 is the shortest and most bioactive fragment of the kisspeptin peptide family, consisting of 10 amino acids derived from the C-terminal region of Kisspeptin-54. It binds with high affinity to the GPR54 (KISS1R) receptor, triggering the release of gonadotropin-releasing hormone (GnRH). Kisspeptin-10 plays a pivotal role in initiating puberty, regulating the reproductive cycle, and maintaining fertility through modulation of the hypothalamic-pituitary-gonadal (HPG) axis.

2. Kisspeptin-10 Structure

【pictures linking，https://pubchem.ncbi.nlm.nih.gov/compound/Kisspeptin-10】

Sequence:YNWNSFGLRF

Molecular Formula:C63H83N17O14

Molecular Weight: 1302.4 g/mol

PubChem CID: 25240297

Synonyms: KISS-1, Protein KISS-1, metastin, Kp-10 peptide

3. Kisspeptin-10 Research

Kisspeptin-10 is a short synthetic peptide fragment derived from the larger kisspeptin family, which are encoded by the KISS1 gene and act as key regulators of the reproductive axis. Kisspeptins bind to the GPR54 receptor (also known as KISS1R) and play a central role in initiating puberty, maintaining fertility, and modulating gonadotropin-releasing hormone (GnRH) secretion.

Kisspeptin-10 (KP-10) is the most potent active fragment and is widely studied for its ability to stimulate the hypothalamic–pituitary–gonadal (HPG) axis with high specificity and minimal systemic disturbance.

【1】 Mechanism of Action

Binds to GPR54 receptors on GnRH neurons, rapidly triggering GnRH release from the hypothalamus
→ PubMed – Kisspeptin and GnRH Axis【https://pubmed.ncbi.nlm.nih.gov/16968783/】

Stimulates LH and FSH secretion from the anterior pituitary, restoring sex hormone levels in both males and females

Plays a role in regulating sexual behavior, ovarian follicle maturation, testosterone production, and spermatogenesis

Works upstream of traditional hormone replacement (e.g. hCG, exogenous testosterone), preserving natural endocrine rhythm

【2】 Key Findings

Kisspeptin-10 administration increases LH/FSH and testosterone in hypogonadal men without suppressing sperm count
→ Journal of Clinical Investigation【https://www.jci.org/】

In women, KP-10 promotes estradiol production, ovulatory function, and endometrial thickness
→ Kisspeptin in fertility – Nature Reviews Endocrinology【https://www.nature.com/articles/nrendo.2013.193】

Demonstrated ability to restore reproductive hormone levels in patients with functional hypothalamic amenorrhea (FHA)

【3】 Expert Insight

Endocrine Society Clinical Guidelines (2020): “Kisspeptin analogs represent a novel class of upstream reproductive modulators, offering a more physiological alternative to exogenous gonadotropins.”

Dr. Waljit Dhillo (Imperial College London): “Kisspeptin can reset the entire reproductive axis without disturbing other hormonal systems.”

✅ Why Consider Kisspeptin-10?

🧬 Stimulates natural GnRH, LH, FSH production

🚫 Avoids testicular shutdown compared to hCG or testosterone

👩‍⚕️ Improves fertility outcomes in both men and women

⚙️ Ideal for post-cycle therapy, HRT restoration, and ovulatory support

🌿 Physiological approach with low side effect profile

🧠 Also linked to mood regulation, libido, and metabolic control

4. Future Kisspeptin-10 Research

A. Functional Hypogonadism & PCT

KP-10 may replace hCG and clomiphene in post-anabolic recovery protocols.

Trials are exploring its ability to reactivate spermatogenesis and restore intrinsic HPG axis in men with suppressed gonadotropins
→ Kisspeptin as PCT – PubMed【https://pubmed.ncbi.nlm.nih.gov/29503308/】

B. Female Reproductive Disorders

Active research in:

Polycystic Ovary Syndrome (PCOS)

Hypothalamic amenorrhea

Luteal phase defects

A 2023 study in Fertility and Sterility showed KP-10 could safely trigger ovulation without overstimulating ovaries like traditional gonadotropins

C. Assisted Reproductive Technologies (ART)

Investigated as an alternative ovulation trigger to hCG in IVF cycles, reducing risk of:

Ovarian Hyperstimulation Syndrome (OHSS)

Multiple births

Kisspeptin’s controlled LH surge may improve embryo quality and implantation rates

D. Neuroendocrine & Metabolic Research

Kisspeptin may influence:

Appetite regulation

Insulin sensitivity

Mood and libido, particularly in estrogen-deficient states
→ Kisspeptin and mood – Journal of Neuroendocrinology【https://pubmed.ncbi.nlm.nih.gov/26537247/】

E. Peptide Combination Therapies

Potentially synergistic with:

GnRH microdose therapy

Follistatin or hMG in fertility regimens

Tesamorelin or CJC-1295 for metabolic modulation and lean mass support

5. Application Area

🧑‍⚕️ Men’s Reproductive Health

Post-cycle therapy (PCT)

Low-T recovery (hypogonadotropic hypogonadism)

Infertility with suppressed LH/FSH
→ Kisspeptin in male HPG axis – PubMed【https://pubmed.ncbi.nlm.nih.gov/25900935/】

👩 Women’s Fertility & Cycle Support

Amenorrhea (FHA)

Ovulation induction

IVF adjunct to reduce OHSS risk
→ Kisspeptin-10 in ART – NCBI【https://pmc.ncbi.nlm.nih.gov/articles/PMC7326063/】

🧪 Endocrine Research & Hormone Mapping

Diagnostic peptide for HPG axis integrity

Functional gonadotropin testing in neuroendocrine clinics

🧠 Mood & Libido Research

KP-10 shows central activity in hypothalamic circuits regulating:

Sexual arousal

Dopaminergic signaling

Estrogen-mediated emotional balance

✅ Summary

Kisspeptin-10 is a neuroendocrine peptide with powerful, targeted effects on the reproductive axis:

✔️ Stimulates GnRH, LH, and FSH in both sexes

✔️ Supports natural testosterone and estrogen production

✔️ Helps restart fertility cycles, ovulation, and libido

✔️ Offers a physiological, upstream alternative to synthetic hormones

✔️ Emerging role in ART, post-cycle therapy, and metabolic health

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The products offered on this website are furnished for in-vitro studies only. In-vitro studies(Latin: in glass) are performed outside of the body. These products are not medicines or drugs and have not been approved by the FDA to prevent, treat or cure any medical condition, ailment or disease. Bodily introduction of any kind into humans or animals is strictly forbidden by law.