KPV 10mg

1. What is KPV?

KPV is a synthetic peptide derived from the C-terminal of the kappa opioid receptor ligand, dynorphin A. It is a three-amino acid peptide with the sequence Lys-Pro-Val. KPV has been studied for its anti-inflammatory, analgesic, and immune-modulating properties. It has been shown to have potential therapeutic applications in conditions such as autoimmune diseases, chronic inflammation, and pain management, as it can modulate the kappa opioid receptor pathways.

2. KPV Structure

【pictures linking，https://pubchem.ncbi.nlm.nih.gov/compound/L-Lysyl-L-prolyl-L-valine】

Amino Acid Sequence: Lys-Pro-Val

Molecular Formula: C16H30N4O4

Molecular Weight: 342.43 g/mol

PubChem CID: 125672

CAS Number: 67727-97-3

Synonyms: MSH (11-13),ACTH(11-13),alpha-MSH(11-13)

3. KPV Research

KPV (Lys-Pro-Val) is a naturally occurring C-terminal tripeptide fragment of the alpha-melanocyte-stimulating hormone (α-MSH). Despite its simplicity, KPV has potent anti-inflammatory, antimicrobial, and epithelial reparative properties without affecting melanogenesis or pigmentation, unlike the parent α-MSH.

Due to its minimal molecular size, KPV is suitable for topical, oral, and systemic applications, making it a promising compound in dermatology, gut inflammation, and immune modulation.

【1】Mechanism of Action

Inhibits NF-κB signaling, a key pathway in the pro-inflammatory cascade
→ NF-κB & Inflammation – NCBI【https://pmc.ncbi.nlm.nih.gov/articles/PMC3491443/】

Suppresses pro-inflammatory cytokines like TNF-α, IL-6, and IL-1β, while sparing beneficial immune responses
→ KPV in cytokine suppression – PubMed【https://pubmed.ncbi.nlm.nih.gov/11207365/】

Promotes epidermal barrier repair and mucosal healing by restoring epithelial cell proliferation and migration

Demonstrates antimicrobial effects, particularly against Staphylococcus aureus and Pseudomonas aeruginosa infections in skin wounds

【2】Clinical & Preclinical Evidence

Topical KPV shown to reduce atopic dermatitis severity, psoriasis-like inflammation, and UV-induced skin damage

Oral and rectal administration alleviated symptoms of colitis, Crohn’s disease, and IBD models in mice
→ KPV in colitis – PubMed【https://pubmed.ncbi.nlm.nih.gov/17057233/】

Also investigated in ocular inflammation, lung fibrosis, and implant rejection

【3】 Expert Insight

Journal of Investigative Dermatology (2022): “KPV is one of the most under-recognized peptides with broad-spectrum anti-inflammatory capability and negligible systemic toxicity.”

Dr. Andrzej Slominski (KPV discoverer): “This tripeptide fragment offers potent local immune modulation without suppressing systemic immunity.”

✅ Why Consider KPV?

✅ Potent anti-inflammatory peptide with minimal size and great bioavailability

💊 Effective in skin, gut, and lung inflammation models

🧬 Does not affect pigmentation unlike other MSH derivatives

🩹 Enhances wound healing, epithelial repair, and microbiome balance

⚙️ Applicable as topical cream, oral capsule, or rectal suppository

🔬 Clinically safe and non-immunosuppressive

4. Future KPV Research

A. Dermatological Therapies

Next-gen topical KPV is being trialed for:

Eczema and psoriasis

Acne vulgaris with bacterial overgrowth

Laser and microneedling recovery

B. Inflammatory Bowel Disease (IBD) and Gut-Brain Axis

Oral and rectal KPV being developed to reduce gut mucosal inflammation without systemic steroids

May protect tight junction proteins in intestinal epithelial barrier
→ KPV in gut permeability – PubMed【https://pubmed.ncbi.nlm.nih.gov/31188455/】

Potential applications in leaky gut, Crohn’s disease, ulcerative colitis, and even gut-derived anxiety

C. Respiratory & Lung Inflammation

Inhaled KPV peptide nanoparticles under research for pulmonary fibrosis, COVID-related lung damage, and chronic bronchitis

D. Cosmetic Peptide Formulations

Combining KPV with GHK-Cu, EGF, and niacinamide in:

Post-laser skin protocols

Redness and pigmentation control

Barrier-supporting moisturizers

E. Antimicrobial Wound Dressing Innovation

KPV-loaded dressings are being tested for:

Burn wounds

Diabetic ulcers

Surgical site infections

5. Application Area

🧖 Dermatology & Skin Repair

Psoriasis

Eczema / dermatitis

Wound & laser recovery
→ Skin barrier research – NCBI【https://pmc.ncbi.nlm.nih.gov/articles/PMC6047195/】

💊 Gastrointestinal Inflammation

Crohn’s disease

Ulcerative colitis

Leaky gut syndrome

🌬️ Lung & Mucosal Health

Lung injury recovery

Asthma inflammation

ARDS / COVID-related fibrosis

🧫 Antimicrobial Uses

Topical bacterial control

Biofilm inhibition

Skin microbiome rebalance

🧬 Adjunctive Therapy

Used with:

BPC-157 for gut

GHK-Cu for skin

TB-500 for systemic inflammation

Melanotan II (if pigmentation is desired separately)

✅ Summary

KPV is a minimal but multifunctional tripeptide offering:

✔️ Strong anti-inflammatory and antimicrobial effects

✔️ Safe for topical, oral, and mucosal applications

✔️ Useful in skin, gut, and respiratory repair

✔️ Non-pigmentary and non-immunosuppressive

✔️ Ideal for chronic inflammation, IBD, and cosmetic peptide stacks