Palmitoyl Pentapeptide 5mg

1. What is Palmitoyl Pentapeptide?

Palmitoyl Pentapeptide (commonly referred to as Palmitoyl Pentapeptide-4 or Matrixyl®) is a synthetic peptide compound used primarily in cosmetic formulations for its anti-aging and skin-rejuvenating properties. It consists of five amino acids linked to a palmitic acid molecule, which enhances its stability and skin penetration. This peptide signals skin cells to increase collagen production, reduce wrinkles, and improve skin elasticity.

2. Palmitoyl Pentapeptide Structure

Molecular Formula：C39H75N7O10

Molecular Weight：802.05g/mol

CAS Number：214047-00-4

3. Palmitoyl Pentapeptide Research

Palmitoyl Pentapeptide-4 (Pal-KTTKS), commercially known as Matrixyl, is a lipid-conjugated peptide fragment derived from the C-terminal of collagen type I (sequence: Lys-Thr-Thr-Lys-Ser) linked to a 16-carbon palmitoyl chain. This lipidation enhances skin penetration, enabling it to function as a biomimetic signal peptide promoting dermal repair and rejuvenation 【https://en.wikipedia.org/wiki/Palmitoyl_pentapeptide-4?utm_source=chatgpt.com】.

【1】Mechanism of Action

Dermal signaling: Mimics collagen fragments, binding receptors on dermal fibroblasts. Activates PRR proteins and downstream pathways (e.g., PKC) to stimulate production of collagen types I/III/IV, elastin, fibronectin, glycosaminoglycans, and hyaluronic acid 【https://www.chemicalbook.com/article/palmitoyl-pentapeptide-biological-roles-mechanisms-of-anti-ageing-efficacy-and-applications.htm?utm_source=chatgpt.com】.

ECM remodeling & protection: Encourages new ECM synthesis while inhibiting collagen degradation—creating intact dermal matrix 【https://journals.sagepub.com/doi/10.1177/22808000251330974?utm_source=chatgpt.com】.

Molecular self-assembly: Nano-aggregate formation in acidic/neutral pH enhances peptide stability and sustained fibroblast activation 【https://en.wikipedia.org/wiki/Proteolipid?utm_source=chatgpt.com】.

Photo-aging defense: Upregulates ECM proteins to counteract UV-induced breakdown in photo-aged skin 【https://pubmed.ncbi.nlm.nih.gov/18492182/】.

【2】 Clinical Evidence

Pilot clinical trials (0.005–3%): Double-blind, split-face study in 93 women (age 35–55) reported –18% wrinkle depth, –37% thickness, and –21% roughness after 12 weeks of twice-daily cream application【https://pubmed.ncbi.nlm.nih.gov/18492182/】.

Higher-dose serum (3–7%): Preliminary studies indicate accelerated wrinkle reduction and improved skin viscoelasticity around the eyes in just 8 weeks .

Tolerability & safety: Multi-study consensus reports excellent tolerability at up to 3% concentration, with minor ocular irritation in rare cases .

Animal studies: Rat wound models show faster healing and collagen deposition with pal-KTTKS patches and creams compared to controls .

✅ Why Consider  Palmitoyl Pentapeptide ?

🧬 Clinically proven anti-wrinkle peptide: Reduces depth and volume of wrinkles in controlled settings.

💪 Boosts ECM protein production: Stimulates collagen, elastin, fibronectin, glycosaminoglycans.

✨ Encourages dermal remodeling: Improves skin firmness, elasticity, hydration, and texture.

💧 Supports barrier & hydration: Enhances hygroscopic molecule production, reducing dryness.

🌿 Non-invasive & gentle: Well-tolerated on sensitive skin, free of irritation.

🔄 Complementary synergy: Works well with retinoids, niacinamide, and SPF; ideal for layering in comprehensive skincare routines .

4. Future Palmitoyl Pentapeptide Research

Optimizing formulations

Nano-/liposomal delivery systems aim to boost dermal delivery and peptide stability【https://www.sciencedirect.com/science/article/pii/S1773224723009395】.

Synergistic blends combining Pal-KTTKS with peptides like palmitoyl tripeptides and niacinamide show enhanced collagen output in vitro 【https://en.wikipedia.org/wiki/Proteolipid?utm_source=chatgpt.com】.

Dose–response & time efficiency

High-concentration serums (7%) demonstrate faster wrinkle reduction in pilot trials—larger RCTs are underway .

Protocols combining Pal-KTTKS with microneedling and light therapy (LED, RF) for dermal stimulation receive growing interest.

Broader dermal applications

Studies exploring use in eczema, post-inflammatory hyperpigmentation, and scar improvement—leveraging ECM repair function.

Early indications suggest anti-inflammatory benefits, though more research is needed.

Aging biomarker research

Biomarker tracking (e.g., pro-collagen levels, skin viscoelasticity, gene expression) aims to personalize peptide dosing.

Peptidomics & structure–activity mapping

Comparative studies of related peptides (Pal-tripeptides, hexapeptides) shed light on sequence-specific structure–activity variations.

5. Application Areas

Daily anti-aging: Evidence-based alternative to retinoids, especially for sensitive skin.

Periorbital treatments: Often included in eye creams to target crow’s feet.

Dermal repair: Accelerates recovery post-procedures like chemical peels, micro-needling, laser.

Hydration and barrier serums: Ideal for dry or mature skin needing ECM support.

Prebiotic skincare formulations: Potential future inclusion in microbiome-supportive cosmeceuticals.

 Summary

Palmitoyl Pentapeptide4 (Matrixyl) is a well-studied signal peptide that mimics collagen fragments to stimulate dermal fibroblasts, promoting ECM regeneration. Clinical data confirm its effectiveness in reducing fine lines, wrinkles, skin roughness, and enhancing texture and hydration. It’s well tolerated, supports sensitive skin needs, and integrates smoothly into multi-active skincare protocols. Current research focuses on improved delivery systems, combination therapies, and broader dermatologic applications.Palmitoyl Pentapeptide4 stands as a scientifically-backed, high-performing peptide in modern anti-aging skincare.

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The products offered on this website are furnished for in-vitro studies only. In-vitro studies(Latin: in glass) are performed outside of the body. These products are not medicines or drugs and have not been approved by the FDA to prevent, treat or cure any medical condition, ailment or disease. Bodily introduction of any kind into humans or animals is strictly forbidden by law