Pinealon 5mg

1. What is Pinealon?

Pinealon is a synthetic peptide derived from the pineal gland, known for its neuroprotective, antioxidant, and anti-aging properties. It is composed of a small sequence of amino acids that modulate the activity of various neuroreceptors, including those involved in regulating circadian rhythms, sleep, and cognitive functions. Pinealon has been studied for its potential to enhance memory, reduce oxidative stress, and protect against age-related neurodegenerative conditions.

2. Pinealon Structure

【pictures linking，https://pubchem.ncbi.nlm.nih.gov/compound/18220191】

Sequence: Glu-Asp-Arg

Molecular Formula: C5H26N6O8

Molecular Weight: 418.4 g/mol

PubChem ClD:18220191

Synonyms: Glutamylaspartylarginine, T-33 pept

3. Pinealon Research

Pinealon is a synthetic tripeptide (GluAspArg) categorized as a bioregulatory peptide—notably small, cell-permeable, and capable of modulating gene expression directly, rather than through surface receptors 【https://en.wikipedia.org/wiki/Pinealon?utm_source=chatgpt.com】.

【1】Cellular Antioxidant & Anti-Apoptotic Effects

Suppresses ROS accumulation in neuronal cells, neutrophils, and PC12 lines—even under oxidative challenges like H₂O₂ or homocysteine—resulting in improved cell survival 【https://en.wikipedia.org/wiki/Pinealon?utm_source=chatgpt.com】.

Delays ERK1/2 activation, modulating cell cycle progression: promotes S/G2 phase entry—a potential regeneration trigger .

Reduces caspase-3 expression in stroke and myocardial injury models, protecting neurons and cardiomyocytes .

【2】Neuroprotective & Cognitive Benefits

In prenatal hyperhomocysteinemia rat models, Pinealon improved offspring spatial memory, lowered brain necrosis and oxidative stress 【https://pmc.ncbi.nlm.nih.gov/articles/PMC3342713/?utm_source=chatgpt.com】.

In aged or hypoxic adult rats, it enhanced resistance to neuron damage, restored norepinephrine rhythms in hypothalamus, and mitigated excitotoxic effects via NMDA modulation .

Promotes irisin expression, linked to mitochondrial energy, telomere length, and neurogenesis .

Potentially epigenetically modulates gene expression tied to memory, stress resilience, and neuroplasticity .

【3】Circadian, Metabolic & Anti-Aging Effects

May normalize pineal function/circadian rhythms, improving sleep, blood pressure, emotional resilience, and stress tolerance .

In older adults with brain syndromes, Pinealon reduced biological aging markers and supported CNS function without DNA damage 【https://pubmed.ncbi.nlm.nih.gov/26390612/】.

It indirectly supports muscle health via irisin and anti-oxidative pathways, suggesting systemic anti-aging properties .

✅ Why Consider Pinealon?

🧠 Neuroprotection & cognition: strengthens neurons, improves memory and stress tolerance

🔬 Antioxidant & regulatory cellular effects: controls ROS, apoptosis, and cell cycle for repair

🕰 Circadian & systemic support: resets rhythms and resilience in aging models

🧬 Epigenetic modulation: likely influences gene expression for lasting impact

⚙️ Aging mitigation: slows functional decline in brain and systemic tissues

🌱 Small-peptide innovation: crosses membranes, acts in nucleus—rare in therapeutic peptides

4. Future Pinealon Research

Epigenetic Gene Mapping

Identify specific genomic targets (e.g. NMDA receptor, irisin pathway, clock genes, casp3, ERK) and their transcriptional modulation.

Clinical Trials in Cognitive Aging & Stroke

Test Pinealon in MCI, stroke recovery, sleep disorders, and circadian disruption in humans.

Peripheral Aging & Muscle Support

Evaluate effects on sarcopenia, muscle endurance, and telomere maintenance via irisin and ROS regulation.

Injury & Organ Protection

Assess cardioprotective roles in MI and neuroprotective impact in ischemic brain injury and neurodegeneration.

Formulation & Delivery

Develop brain-targeted oral, intranasal, or nanoparticle systems for enhanced CNS bioavailability.

Combination Therapies

Synergistic protocols with Epitalon, NAD⁺ boosters, or other peptides to address multi-pathway aging.

5. Application Areas

Cognitive health & neurodegeneration: MCI, Alzheimer’s, age-related memory decline

Stroke & brain injury recovery: reducing necrosis and improving neuroplasticity

Circadian disorders: jet lag, shift work, sleep disturbances

Cardiac repair: post-MI apoptosis reduction, tissue remodeling support

Longevity & systemic resilience: antioxidant defense, irisin-mediated metabolism, telomere preservation

Sports & recovery: supporting endurance and reducing oxidative stress in athletes

✅ Summary

Pinealon is a tripeptide geroprotector with strong potential in neuroprotection, antioxidant regulation, gene modulation, and anti-aging resilience. Acting via intracellular/nuclear entry and precise redox/cell-cycle signaling, it preserves brain and systemic health in preclinical models. Translational research is underway to bring its multi-domain benefits—sleep, cognition, circadian rhythm, recovery—to therapeutic application and everyday wellness.

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The products offered on this website are furnished for in-vitro studies only. In-vitro studies(Latin: in glass) are performed outside of the body. These products are not medicines or drugs and have not been approved by the FDA to prevent, treat or cure any medical condition, ailment or disease. Bodily introduction of any kind into humans or animals is strictly forbidden by law.