Vilon 5mg

1. What is Vilon?

Vilon is a synthetic peptide derived from thymic tissue, known for its immune-modulating and tissue repair properties. It is composed of a sequence of amino acids that help regulate immune responses, reduce inflammation, and promote healing in damaged tissues. Vilon has been studied for its potential use in treating conditions like autoimmune diseases, chronic inflammation, and tissue degeneration, making it an important tool in regenerative medicine.

2. Vilon Structure

Molecular Formula：C11H21N3O5

Molecular Weight：257.30g/mol

CAS Number：45234-02-4

3. Vilon Research

Vilon, a synthetic dipeptide of lysine and glutamic acid (Lys–Glu), is among the smallest biologically active peptides ever discovered. Originating from Russian peptide biology research—specifically the Khavinson school—it has gained widespread attention for its epigenetic, immunomodulatory, and anti-aging effects ([turn0search8]). It has been the subject of over 25 years of studies, including key contributions from Anisimov, Khavinson, and colleagues.

Mechanistic Highlights

Epigenetic activation: Vilon promotes chromatin decompaction, reactivating silent genes (e.g., ribosomal, immune, regenerative) without affecting centromeric heterochromatin stability, yielding systemic rejuvenation ([turn0search8]).

Immune rejuvenation: Promotes thymocyte proliferation and CD5/CD4/CD8 cell differentiation in thymic cultures, supports splenic T-cell proliferation, and helps rebalance lymphocyte/granulocyte counts after radiation exposure ([turn0search2], [turn0search5]).

Anti-cancer properties: In vitro, Vilon strongly inhibited proliferation of human colon (LOVO), gastric (MKN45), and hepatic (QGY7703) cancer cells, while sparing healthy leukocytes ([turn0search12]). In vivo, Vilon reduced tumor growth in H22 hepatoma mice by over 60% at 30 mg/kg, and decreased spontaneous tumor incidence in long-term aging studies ([turn0search0], [turn0search12]).

Longevity & physical function: Mice administered Vilon from age 6 months displayed increased activity, endurance, reduced body temperature, extended lifespan, and reduced cancer rates—without disrupting reproductive function or redox balance ([turn0search0], [turn0search16]).

Gastrointestinal support: Oral Vilon improved active and passive glucose absorption in aged rat small intestines, suggesting enhanced nutrient uptake and digestive resilience ([turn0search6]).

Cardiovascular & renal roles: Gene expression studies show Vilon modulates over 36 heart genes (144 when combined with Epithalon), reduces TGFβ1 levels, enhances antithrombin III and protein C, and promotes fibrinolysis—favoring vascular and coagulation health ([turn0search16], [turn0search8]).

Neuro-ocular regeneration: Animal research indicates Vilon supports retinal and neuronal repair via cell proliferation and wound healing pathways ([turn0search2]).

Anti-inflammatory modulation: In THP-1 macrophage models, Vilon inhibited LPS-induced TNF and IL6 production while activating MAPK signaling (ERK/JNK) to promote proliferation and immune balance ([turn0search2]).

✅ Why Consider Vilon?

🌟 Epigenetic rejuvenation: Reactivates silenced genes to restore cellular youthfulness and functional capacity.

💪 Immune system support: Optimizes T-cell populations, promotes immune resilience, and accelerates post-radiation recovery.

🎯 Natural anti-cancer potential: Demonstrated inhibition of tumor growth in preclinical models.

🕰 Longevity enhancer: Boosts endurance and lifespan in mice with early-life administration.

🍽 Digestive improvement: Enhances nutrient absorption, vital for aging or malabsorption conditions.

🫀 Cardio-renal balance: Supports healthier vascular gene expression and coagulation pathways.

🧠 Reparative regeneration: Stimulates neural and ocular repair circuits.

🔄 Ideal for peptide synergy: Complements other geroprotectors like Epitalon or Thymogen.

🌍 Minimal formula, broad impact: A tiny dipeptide with system-wide benefits.

4. Future Vilon Research & Innovation

Human clinical trials
Validate epigenetic, immune, longevity, and anti-cancer effects in randomized settings.

Transcriptomic profiling
Explore specific gene expression changes in immune, heart, renal, and neural tissues.

Onco-preventive studies
Evaluate Vilon’s cancer-preventing capabilities in individuals with pre-malignant conditions.

Gastrointestinal and metabolic trials
Investigate improved nutrient absorption and potential metabolic benefits in older adults.

Cardiovascular/hematologic endpoints
Monitor coagulation markers, blood pressure, and kidney function in metabolic disease.

Neuro-ophthalmological research
Pilot therapies targeting mild cognitive decline or retinal injury.

Delivery system development
Create sustained-release injections, microdosing pens, or oral encapsulated forms for convenience.

5. Application Areas

Summary

Vilon is a minimal yet powerful dipeptide bioregulator with documented effects in epigenetic modulation, immune rejuvenation, anti-cancer activity, longevity enhancement, digestive support, and vascular stabilization. Its multi-system benefits, backed by decades of preclinical data, position it as a versatile pillar in anti-aging, immunity, regenerative, and preventive wellness strategies. As next-generation delivery systems and human studies emerge, Vilon is poised to become a cornerstone peptide for comprehensive health transformation.

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The products offered on this website are furnished for in-vitro studies only. In-vitro studies(Latin: in glass) are performed outside of the body. These products are not medicines or drugs and have not been approved by the FDA to prevent, treat or cure any medical condition, ailment or disease. Bodily introduction of any kind into humans or animals is strictly forbidden by law.