1. What is IGF-1 LR3?
IGF-1 LR3 (Long R3 Insulin-like Growth Factor-1) is a synthetic analog of human IGF-1 designed for enhanced stability and potency. It differs from native IGF-1 by having an extended amino acid chain and a substitution of arginine for glutamic acid at position 3. IGF-1 LR3 promotes cellular growth, repair, and regeneration, and has been extensively studied in muscle development, tissue repair, and anti-aging research.
2. IGF-1 LR3 Structure
【pictures linking，https://www.ebi.ac.uk/pdbe/entry/pdb/1gzr】
Sequence: MFPAMPLSSL FVNGPRTLCG AELVDALQFV CGDRGFYFNK PTGYGSSSRR APQTGIVDEC CFRSCDLRRL EMYCAPLKPA KSA
Molecular Formula:C400H625N111O115S9
Molecular Weight: 9117.5 g/mol
CAS Number: 946870-92-4
3. IGF-1 LR3 Research
IGF-1 LR3 (Insulin-like Growth Factor 1 Long Arg3) is a synthetic analog of human IGF-1, modified to increase its stability, bioactivity, and resistance to IGF-binding proteins (IGFBPs). It contains a 13–amino-acid extension at the N-terminus and a substitution of arginine for glutamic acid at position 3, which significantly prolongs its half-life and enhances its biological availability.
Whereas native IGF-1 has a half-life of 12–18 hours in circulation, IGF-1 LR3 remains active for up to 20–30 hours, allowing for more consistent anabolic, neurological, and regenerative effects.
【1】Mechanism of Action
Binds IGF-1 Receptors (IGF-1R): IGF-1 LR3 mimics insulin’s anabolic actions, promoting cell growth, proliferation, and protein synthesis, especially in skeletal muscle, cartilage, and neuronal tissues.
Inhibits Apoptosis: Supports cell survival and reduces catabolism in muscle, skin, and neural systems 【https://pubmed.ncbi.nlm.nih.gov/9716415/】.
Independent from IGFBPs: Unlike native IGF-1, IGF-1 LR3 avoids sequestration by binding proteins, ensuring more free active hormone.
【2】 Key Clinical and Performance Effects
💪 Increases muscle fiber size by enhancing satellite cell activity and myoblast fusion
🔁 Improves tissue repair in muscles, tendons, skin, and even cardiac tissue
🧠 Supports neuroregeneration, neuroplasticity, and cognitive restoration
🩹 Enhances wound healing and collagen production
🔬 Modulates glucose metabolism, increases nutrient uptake, and improves insulin sensitivity in muscle
【3】 Expert Commentary
Journal of Molecular Endocrinology (2020): “LR3’s resistance to IGFBPs allows it to deliver higher anabolic potency with less dosage and frequency.”
Dr. Mauro Di Pasquale (Hormone Researcher): “IGF-1 LR3 is one of the most effective tools for muscle regeneration and systemic recovery if used correctly and timed around tissue demand.”
✅ Why Consider IGF-1 LR3?
💥 10x biological activity over native IGF-1 due to IGFBP resistance
🧬 Promotes muscle hypertrophy, collagen synthesis, and stem cell activation
🧠 Supports brain plasticity, neurogenesis, and nerve healing
🛠️ Useful for injury recovery, surgery support, and tendon/ligament regeneration
🔄 Enhances fat loss and glucose utilization in muscle tissues
⏳ Long half-life = fewer injections, more stable plasma exposure
4. Future IGF-1 LR3 Research
A. Musculoskeletal Regeneration & Orthopedic Use
IGF-1 LR3 is under exploration in:
Rotator cuff repair
ACL reconstruction
Tendinopathy treatment
Expected to become an adjuvant therapy alongside PRP and stem cell infusions
→ PubMed: IGF-1 in muscle healing【https://pubmed.ncbi.nlm.nih.gov/16322652/】
B. Cognitive & Neurodegenerative Disease
Ongoing trials are examining IGF-1 LR3’s ability to improve:
Cognitive function in Alzheimer’s disease
Neuroplasticity after stroke
Motor neuron recovery in ALS models
C. Anti-Aging & Longevity Medicine
Part of peptide-based “regenerative stacks” for age-related decline in:
Muscle mass
Skin collagen
Cognitive performance
Stacks include GH secretagogues, Epitalon, and Follistatin
D. Oncology Risk & Safety Studies
Due to IGF-1’s role in cell proliferation, long-term LR3 use raises concerns for:
Tumor promotion
Insulin resistance if overdosed chronically
Studies are ongoing to define safe dosing limits and intermittent use protocols
E. Combination Therapies
Potentially synergistic with:
CJC-1295 + GHRP-2 or Hexarelin → boosts GH to increase endogenous IGF-1
BPC-157 or TB-500 → amplifies tissue repair
GHK-Cu → enhanced collagen synthesis and anti-wrinkle effect
5.Application Area
💪 Muscle Growth & Injury Repair
Used in: Body recomposition programs
Post-injury rehab (muscle tears, tendonitis)
P ost-op surgical support
🧠 Neuroregeneration
May benefit: Stroke rehabilitation
Peripheral nerve injuries
Cognitive burnout
🧪 Skin, Wound & Anti-Aging Therapy
Improves: Collagen density
Epithelial regeneration
Post-ablative wound healing
→ IGF in Dermatology – Springer【https://link.springer.com/article/10.1007/s13555-021-00576-y】
🧁 Metabolic Optimization
Enhances: Insulin sensitivity in muscle
Glucose disposal post-meal
Fat oxidation under GH co-administration
✅ Summary
IGF-1 LR3 is one of the most potent regenerative peptides available today, offering:
✔️ Strong muscle growth, neuroprotection, and tissue repair
✔️ Extended activity through IGFBP resistance
✔️ Promising support in orthopedic, cognitive, and skin healing fields
✔️ Compatible with CJC-1295, Follistatin, BPC-157, and GH therapies
✔️ Under active study in longevity medicine, brain recovery, and metabolic health
ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATONAL AND EDUCATIONAL PURPOSES ONLY.
The products offered on this website are furnished for in-vitro studies only. In-vitro studies(Latin: in glass) are performed outside of the body. These products are not medicines or drugs and have not been approved by the FDA to prevent, treat or cure any medical condition, ailment or disease. Bodily introduction of any kind into humans or animals is strictly forbidden by law.
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