Melanotan-2 10mg

1. What is Melanotan-2?

Melanotan II is a synthetic peptide analog of the alpha-melanocyte-stimulating hormone (α-MSH), designed to stimulate melanogenesis, the process responsible for skin tanning. It also has effects on sexual function and appetite regulation. Initially developed to reduce UV exposure by enhancing natural pigmentation, Melanotan II is now studied for its potential roles in photoprotection, libido enhancement, and metabolic regulation.

2. Melanotan-2 Structure

【pictures linking，https://pubchem.ncbi.nlm.nih.gov/compound/92432】

Sequence: Nle-Asp(1)-His-D-Phe-Arg-Trp-Lys(1)

Molecular Formula:C50H69N15O9

Molecular Weight:1024.198 g/mol

PubChem CID: 92432

CAS Number:121062-08-6

3.Melanotan2 Research

Melanotan2 (MTII) is a synthetic peptide analog of α-Melanocyte-Stimulating Hormone (αMSH). It was initially developed to stimulate melanin production for UV protection, but it soon revealed multi-systemic physiological effects, including sexual arousal, appetite suppression, and energy balance modulation.

Structurally enhanced for greater stability and half-life, MTII activates melanocortin receptors—primarily MC1R, but also MC3R, MC4R, and MC5R. This broad receptor activity results in both cosmetic tanning and neuroendocrine effects.

Key Functional Pathways:

🧴 Pigmentation: MTII binds to MC1R on melanocytes, enhancing eumelanin synthesis. This produces a darker skin tone even without UV exposure .

❤️ Sexual Arousal: Via MC4R activation in the hypothalamus, MTII induces spontaneous erections in men and increases libido in both sexes 【https://dermnetnz.org/topics/melanotan-ii?utm_source=chatgpt.com】.

🍽️ Appetite Suppression: MC4R is also involved in energy regulation, promoting reduced hunger and potential fat loss 【https://www.actasdermo.org/en-melanotan-articulo-resumen-S1578219012001382?utm_source=chatgpt.com】.

🛡️ Immune & Cardiovascular Effects: MTII exhibits anti-inflammatory properties, though some reports associate it with transient hypertension and tachycardia.

Human Observations & Side Effects:

Clinical and anecdotal data suggest rapid effects:

Tanning appears after 4–7 injections during a “loading phase”.

Sexual effects can occur within hours of administration.

Common side effects: flushing, nausea, increased yawning, fatigue, decreased appetite, and darkening of moles or freckles.

Rare complications: rhabdomyolysis, renal infarction, and potential mole dysplasia have been reported in isolated cases 【https://pmc.ncbi.nlm.nih.gov/articles/PMC7148395/?utm_source=chatgpt.com】.

✅ Why Consider Melanotan2?

🌞 Provides fast, visible tanning without excessive sun exposure

❤️ Promotes sexual arousal and spontaneous erections in both sexes

🍽️ Aids in appetite control, supporting fat loss and energy regulation

🛡️ Delivers potential anti-inflammatory benefits through MC receptors

⏳ Sustained pigment response lasting weeks after treatment

🧪 Promising for research into body image, libido, and metabolism

4. Future Melanotan2 Research

A. Selective Receptor Derivatives

Efforts are ongoing to create analogs that target MC4R only, excluding pigmentation effects. Bremelanotide (PT-141) is a success story here—preserving sexual benefits while eliminating tanning 【https://en.wikipedia.org/wiki/Bremelanotide?utm_source=chatgpt.com】.

B. Novel Delivery Methods

Research focuses on nasal sprays, transdermal patches, and long-acting subdermal implants, aiming to reduce side effects while improving adherence.

C. Long-Term Dermatologic Monitoring

MTII’s mole-darkening effects raise concerns about melanoma mimicry. Studies are underway to clarify whether these changes are benign or carry oncological risk 【https://pmc.ncbi.nlm.nih.gov/articles/PMC11664455/?utm_source=chatgpt.com】.

D. Weight Loss & Metabolism

Since MC4R is tied to hunger and energy expenditure, MTII is being evaluated in obesity trials as an appetite suppressant and metabolic modulator.

E. Autoimmune & Inflammatory Research

Emerging evidence suggests MTII may aid in inflammatory skin diseases, like psoriasis or eczema, and gut inflammation such as IBD, though clinical trials are limited 【https://pmc.ncbi.nlm.nih.gov/articles/PMC10265466/?utm_source=chatgpt.com】

5.Application Area

Cosmetic Dermatology: Skin darkening, pigmentation regulation

Sexual Health: Research into erectile dysfunction and low libido

Weight Management: Appetite control and fat-loss support

Photoprotection: Increased UV resistance and eumelanin synthesis

Neuroendocrine Research: Appetite, arousal, stress modulation pathways

⚠️6. Safety & Legal Considerations

❌ Not approved by regulatory authorities (FDA, EMA, TGA)

🧪 Sold as unregulated research chemical—high risk of contamination

🔬 Requires dermatologic supervision due to mole darkening

😷 Potential risks: vomiting, hypertension, hormonal imbalance

📋 No long-term safety profile available for chronic use

ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATONAL AND EDUCATIONAL PURPOSES ONLY.

The products offered on this website are furnished for in-vitro studies only. In-vitro studies(Latin: in glass) are performed outside of the body. These products are not medicines or drugs and have not been approved by the FDA to prevent, treat or cure any medical condition, ailment or disease. Bodily introduction of any kind into humans or animals is strictly forbidden by law.