MGF 2mg

1. What is MGF?

MGF (Mechano Growth Factor) is an alternatively spliced variant of IGF-1 (Insulin-like Growth Factor-1) that is expressed in response to mechanical stress or muscle damage. It plays a vital role in muscle repair, growth, and regeneration by activating satellite cells and stimulating local protein synthesis. MGF is particularly important during the early stages of muscle recovery.

2. MGF Structure

Molecular Formula: C121H200N42O39

Molecular Weight:2644.9g/mol

CAS Number: 57773-63-4

3. MGF Research

MGF, also known as IGF1Ec (human) or IGF1Eb (rodent), is an alternatively spliced isoform of IGF1, generated in response to mechanical stress or muscle damage. Its unique E-domain grants it distinct functionality separate from IGF1Ea, triggering rapid tissue responses.

【1】Mechanism of Action & Expression

Induced within hours of mechanical overload, MGF appears before IGF1Ea, signaling immediate recovery priorities【https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2018.00999/full?utm_source=chatgpt.com】.

Activates muscle satellite cell proliferation, kicks off early hypertrophic signals, and enhances myoblast differentiation 【https://journals.physiology.org/doi/full/10.1152/ajpendo.00408.2013?utm_source=chatgpt.com】.

Has a strong autocrine/paracrine pattern—acts locally to boost IGF1 sequestration at injury sites 【https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2018.00999/full?utm_source=chatgpt.com】.

【2】AntiInflammatory & Immunomodulatory Effects

MGF is produced by infiltrating macrophages post-injury and modulates inflammatory resolution, delaying macrophage apoptosis and cytokine clean-up 【https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2018.00999/full?utm_source=chatgpt.com】.

Shifts immune responses toward balanced repair rather than unchecked inflammation.

【3】Tissue Protection Beyond Muscle

MGF promotes chondrocyte proliferation and cartilage repair【https://pmc.ncbi.nlm.nih.gov/articles/PMC10281885/?utm_source=chatgpt.com】.

It protects tissues from mechanical overloading, reducing apoptosis in shear or ischemic stress scenarios 【https://www.sciencedirect.com/science/article/abs/pii/S0014482718300958?utm_source=chatgpt.com】.

【4】Neuro-regenerative Functions

Overexpressed MGF in mice supports adult neurogenesis, especially in hippocampus/olfactory areas, and rescues age-related neuronal loss 【https://molecularbrain.biomedcentral.com/articles/10.1186/s13041-017-0304-0?utm_source=chatgpt.com】

In ischemic brain models, MGF provides significant neuroprotection, outperforming IGF1Ea in neuron salvage 【https://molecularbrain.biomedcentral.com/articles/10.1186/s13041-017-0304-0?utm_source=chatgpt.com】.

✅ Why Consider MGF?

🏋️ Rapid muscle recovery & growth—activates satellite cells immediately post-stress

🛠️ Reduces inflammation by modulating macrophage activity

💎 Tissue-specific repair without systemic IGF-1 side effects

🦴 Supports cartilage health, joint integrity

🧠 Enhances neurogenesis & brain repair, valuable for aging or injury

⏳ PEGMGF forms extend effect duration, enabling fewer doses

4. Future MGF Research

A. Therapeutic Muscle & Cartilage Regeneration

PEGMGF peptides are in development to enhance satellite cell activation, improving outcomes in muscle-wasting diseases and joint repair 【https://pmc.ncbi.nlm.nih.gov/articles/PMC10281885/?utm_source=chatgpt.com】【https://molecularbrain.biomedcentral.com/articles/10.1186/s13041-017-0304-0?utm_source=chatgpt.com】.

Combined with cell therapies (e.g., satellite cell transplants), MGF boosts host integration and tissue regeneration【https://www.amjtransplant.org/article/S1600-6135%2822%2912608-0/pdf?utm_source=chatgpt.com】.

B. Inflammation Modulation

Further studies needed to define MGF’s effect on chronic inflammation, post-injury immune regulation, and autoimmune conditions, leveraging its inflammatory signaling control.

C. Neurological & CNS Applications

Promising data exist for neurogenesis and neuroprotection—conditions like stroke, Alzheimer’s, and Parkinson’s are potential targets【https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2018.00999/full?utm_source=chatgpt.com】.

Timing may be critical: early life vs late, young vs aged responses differ significantly.

D. Cardiovascular & Organ Protection

Research supports MGF’s protective effect in ischemic tissues (including the heart), preventing cell death post-injury .

Potential use in heart attack recovery and organ transplant survival protocols.

E. Delivery Technologies & Safety Profiling

Development of PEGylation, microsphere, or hydrogel systems to prolong bioactivity.

Safety profiling (tumorigenicity risk, off-target proliferation) is ongoing, with early data indicating limited systemic effects.

5. Application Area

Musculoskeletal Repair: Ligament, tendon, and skeletal muscle recovery (injury, surgery, aging)

Osteoarthritis / Cartilage Regrowth: Through chondrocyte proliferation

Neurological Regeneration: Brain aging, stroke recovery, neurodegenerative support

Cardiometabolic Healing: Organ preservation after ischemia or transplant

Sports Medicine & Longevity: Performance recovery, age-related degeneration support

⚠️6. Safety & Considerations

Mostly studied in animal and preclinical settings—human trials are limited

Must avoid use in cancer-risk scenarios, as growth signals might exacerbate proliferation

PEG-MGF dosing protocols require careful design to minimize immune response or scar tissue

Quality of synthetic MGF products varies—research-grade purity and validation is essential

✅ Summary

MGF is a versatile tissue-specific growth signal, initiating rapid satellite cell activation, inflammation balance, and cell survival mechanisms across muscle, cartilage, heart, and brain tissues. PEG modifications enable longer activity, improving practicality for therapeutic use. As research deepens—from stem cell engraftment to neurodegeneration—the promise of MGF lies in its precision-targeted regenerative potential.

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The products offered on this website are furnished for in-vitro studies only. In-vitro studies(Latin: in glass) are performed outside of the body. These products are not medicines or drugs and have not been approved by the FDA to prevent, treat or cure any medical condition, ailment or disease. Bodily introduction of any kind into humans or animals is strictly forbidden by law.