NMN 500mg

1. What is NMN?

NMN (Nicotinamide Mononucleotide) is a naturally occurring compound and a direct precursor to NAD⁺ (Nicotinamide Adenine Dinucleotide), a vital coenzyme involved in energy metabolism, DNA repair, and cellular longevity. NMN supplementation is widely studied for its potential to restore intracellular NAD⁺ levels, especially as they decline with age, and to support healthy aging and metabolic function.

2. NMN Structure

Molecular Formula：C11H15N2O8P

Molecular Weight：334.22g/mol

CAS Number：1094-61-7

3. NMN Research

【1】Basic Biology & Pathways

NMN is a key metabolic precursor to NAD⁺, synthesized from vitamin B₃ via the NAMPT enzyme and converted by NMNAT into NAD⁺ within cells. It’s naturally present in foods like broccoli, avocado, cabbage, and also secreted by adipose tissue via eNAMPT vesicles, playing a role in tissue-to-tissue NAD⁺ distribution 【https://pmc.ncbi.nlm.nih.gov/articles/PMC7238909/?utm_source=chatgpt.com】.

【2】 Age-Related Decline & NAD⁺ Resilience

NAD⁺ levels naturally decline with age, stress, obesity, and chronic disease. NMN supplementation restores NAD⁺ bioavailability, supporting mitochondrial function, energy metabolism, DNA repair, and overall cellular resilience 【https://www.mdpi.com/1422-0067/25/17/9526?utm_source=chatgpt.com】.

【3】In Vivo & Cellular Effects

Metabolic & insulin sensitivity: NMN reduces adipose inflammation, enhances insulin secretion/action, and rebalances metabolic hormones in mice【https://pmc.ncbi.nlm.nih.gov/articles/PMC7238909/?utm_source=chatgpt.com】.

Muscle & performance: A 250 mg/day regimen in older adults improved walking speed and grip strength over 6–12 weeks 【https://www.nature.com/articles/s41514-022-00084-z?utm_source=chatgpt.com】.

Cardiovascular protection: Emerging evidence suggests NMN alleviates arterial stiffness and protects against ischemia/reperfusion damage 【https://www.mdpi.com/1422-0067/25/17/9526?utm_source=chatgpt.com】.

Neuroprotection & cognition: Animal studies show NMN preserves blood-brain barrier integrity, promotes neuron survival in Alzheimer’s models, and supports cognitive networks 【https://pmc.ncbi.nlm.nih.gov/articles/PMC7238909/?utm_source=chatgpt.com】.

DNA repair & anti-aging pathways: NAD⁺ from NMN fuels sirtuins and PARPs, protecting genomic stability and reducing oxidative stress 【https://en.wikipedia.org/wiki/Nicotinamide_mononucleotide?utm_source=chatgpt.com】.

Digestive system & inflammation: Research suggests NMN may alleviate age-related digestive disorders via anti-inflammatory modulation 【https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-024-05614-9?utm_source=chatgpt.com】.

【4】Emerging Functions

NMN is being explored as a non-natural cofactor in synthetic biology to drive targeted enzymatic pathways 【https://www.mdpi.com/2073-4344/15/1/37?utm_source=chatgpt.com】.

Animal studies show NMN improves allodynia, recovery following chemo/radiotherapy, and acts systemically as a longevity-supportive molecule 【https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2024.1436597/full?utm_source=chatgpt.com】.

✅ Why Consider NMN?

⚡ Metabolic Enhancement – boosts insulin sensitivity, mitochondrial output, and energy expenditure.

🏃 Physical Performance Gains – improves muscle function, endurance, and gait in older adults.

❤️ Cardiovascular Support – reduces arterial stiffness and protects the heart under stress.

🧠 Cognitive & Neuro Support – enhances neuron resilience, barrier integrity, and may slow cognitive aging.

🛡 Genomic & Cellular Defense – promotes DNA repair, sirtuin activity, and resistance against oxidative damage.

🍽 Digestive & Inflammatory Balance – potential benefits for gut health and chronic systemic inflammation.

🧪 Blue-Sky Applications – enabling synthetic biology, cofactor engineering, and biomolecular innovation.

4. Future NMN Research

【1】Advanced Human Trials
Ongoing placebo-controlled trials with doses from 250 mg to 1,250 mg daily—spanning older adults to prediabetic subjects—targeting parameters such as NAD⁺ levels, muscle strength, metabolic function, and vascular health 【https://www.probiologists.com/article/insight-into-the-application-of-nicotinamide-mononucleotide-nmn-to-age-related-disorders?utm_source=chatgpt.com】.

【2】Delivery Optimization
Investigations into oral NR/NMN, IV infusions, intranasal, transdermal, and probiotic-expressed NMN seek enhanced bioavailability and compliance .

【3】 Cardiometabolic & Immune Applications
Research targets hypertension, vascular aging, autoimmunity, chronic inflammation, NAFLD, and metabolic syndrome【https://www.mdpi.com/1422-0067/25/17/9526?utm_source=chatgpt.com】.

【4】 Neurodegeneration & Longevity Trials
Expanding studies into early cognitive support, blood-brain barrier protection, and DNA damage repair—high-tech labs are focusing on Alzheimer’s, glaucoma, and age-related decline 【https://pmc.ncbi.nlm.nih.gov/articles/PMC10917541/?utm_source=chatgpt.com】.

【5】 Synthetic Biology & Metabolic Engineering
Advancements in cofactor-based enzyme design, AI-guided biosynthetic pathways, and cell-free metabolic platforms utilize NMN as a building block for bioengineered therapies【https://www.mdpi.com/2073-4344/15/1/37?utm_source=chatgpt.com】.

【6】 Mechanistic Deep-Dive
Ongoing work explores NAD⁺ turnover via CD38, mitochondrial-nuclear crosstalk, tissue-specific kinetics, and aging-related pharmacodynamics 【https://en.wikipedia.org/wiki/CD38-IN-78c?utm_source=chatgpt.com】

5. Application Areas

Anti-aging & Longevity: NAD⁺ restoration supports smart-based aging approaches.

Athletic & Physical Rehab: Enhances recovery, muscle resilience, and metabolism.

Metabolic Health: Relevant for prediabetes, insulin resistance, and weight stability.

Cardiovascular Wellness: May reduce arterial aging and risk of metabolic-cardiovascular events.

Neuro-support: Potential adjunct in early cognitive impairment therapies.

Immune & Gut Health: Offers systemic support against inflammaging and barrier decline.

Precision Biotech: Coenzyme engineering, enzyme synthesis, and advanced pharmacology.

 Summary

NMN is a powerful NAD⁺ precursor with broad, multi-system benefits—ranging from metabolic vitality and muscle performance to cardiovascular resilience and cognitive support. Extensive preclinical and emerging clinical data support its role in healthy aging, exercise performance, neuroprotection, and DNA repair. With systemic delivery optimization, longevity integration, and synthetic biology applications on the horizon, NMN is emerging as a key pillar in both wellness and future therapeutic landscapes.

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The products offered on this website are furnished for in-vitro studies only. In-vitro studies(Latin: in glass) are performed outside of the body. These products are not medicines or drugs and have not been approved by the FDA to prevent, treat or cure any medical condition, ailment or disease. Bodily introduction of any kind into humans or animals is strictly forbidden by law.