Semax 5mg

1. What is Semax?

Semax is a synthetic peptide derived from the adrenocorticotropic hormone (ACTH 4–10) fragment, developed in Russia for its neuroprotective, nootropic, and cerebrovascular-regulating properties. It is widely used in neurological research for its ability to improve cognitive performance, enhance memory, and protect neurons under stress or injury. Semax is classified as a nootropic and neuropeptide with clinical applications in stroke recovery, ischemia, and neurodegeneration.

2. Semax Structure

【pictures linking，：https://pubchem.ncbi.nlm.nih.gov/compound/122178】

Sequence: Ac-Met-Glu-His-Phe-Pro-Gly-Pro

Molecular Formula: C37H51N9O10S

Molecular Weight: 813.9 g/mol

PubChem ClD:122178

CAS Number: 80714-61-0

Synonyms: Pro-Gly-Pro-ACTH

3. Semax Research

Semax is a synthetic heptapeptide analog of ACTH(4–10)—sequence MetGluHisPheProGlyPro—engineered to resist enzymatic breakdown (via the added ProGlyPro tail) and retain potent neuroprotective and nootropic propertie.

【1】Molecular Mechanisms & Neurotrophic Effects

Activates melanocortin receptors in the brain, influencing neuronal survival, mood, and cognition .

Upregulates BDNF and TrkB receptor expression in the hippocampus within hours, enhancing synaptic plasticity, neurogenesis, and cognitive resilience .

Modulates monoamines—elevating dopamine, serotonin, and norepinephrine—supporting attention, mood stabilization, and anti-fatigue functions 【https://en.wikipedia.org/wiki/Semax?utm_source=chatgpt.com】.

Exhibits antioxidant and anti-inflammatory actions, reducing neuronal oxidative stress and inflammatory cytokines【https://pmc.ncbi.nlm.nih.gov/articles/PMC3987924/?utm_source=chatgpt.com】.

Alters transcription of genes in neurotransmission, vascular growth, and immune signaling, as shown in stroke models, offsetting damage from ischemia 【https://pmc.ncbi.nlm.nih.gov/articles/PMC3987924/?utm_source=chatgpt.com】.

【2】 Preclinical Effects (Rodents)

Improves cognitive outcomes in ischemia (MCAO) models—reducing infarct volumes and supporting learning performance.

Enhances memory and focus in passive-avoidance and water-maze tasks .

Protects against oxidative neuronal damage and normalizes inflammation-driven vascular injury 【https://pubs.acs.org/doi/10.1021/acschemneuro.1c00707?utm_source=chatgpt.com】.

【3】Clinical & Translational Research

Two Russian pilot studies in healthy adults (1–1.2 mg intranasal) saw enhanced attention, working memory, and fMRI activation in default-mode networks【https://www.alzdiscovery.org/uploads/cognitive_vitality_media/Semax-Cognitive-Vitality-For-Researchers.pdf?utm_source=chatgpt.com】.

In stroke patients, Semax increased plasma BDNF and correlated with faster early rehabilitation outcomes .

Initial data in surgical peptic ulcer recovery showed improved healing rates, though further trials are needed 【https://en.wikipedia.org/wiki/Semax?utm_source=chatgpt.com】.

✅ Why Consider Semax?

🧠 Cognitive boost: Enhances focus, memory, and mental clarity via BDNF and monoamine modulation.

🛡 Neuroprotective: Shields the brain from oxidative damage, neuroinflammation, and ischemic injury.

🌿 Mood & stress resilience: Bolsters dopamine/serotonin pathways and modulates stress-responsive genes.

🧬 Transcriptomic modulation: Activates neurogenesis and vascular repair while tempering inflammation after stroke.

🌍 Emerging clinical use: Used in Russia/Eastern Europe for stroke, cognitive decline, ulcers, and light mental fatigue 【https://en.wikipedia.org/wiki/Semax?utm_source=chatgpt.com】.

⚙️ Practical administration: Intranasal delivery allows self-application with fast action and high patient compliance.

4. Future Semax Research

Larger Human Trials

Expand on pilot studies with focus on cognitive enhancement, post-stroke recovery, and mood disorders.

Mechanistic Transcriptome Studies

Build upon RNA-seq work to map Semax-driven neurogenesis, inflammation, and synaptic gene expression profiles 【https://en.wikipedia.org/wiki/Semax?utm_source=chatgpt.com】.

Disease-Specific Clinical Use

Plan trials in Alzheimer’s, Parkinson’s, TBI, and ADHD, leveraging its neurotrophic effects.

Combination Modalities

Combine with Selank, NAD+ boosters, or light/rehab therapies to maximize neuroenhancement.

Formulation Optimization

Develop stable intranasal, injectable, or time-release systems for sustained central activity.

Transcript-to-Function Validation

Link gene-level changes to functional outcomes like learning, memory consolidation, and vascular integrity.

5. Application Areas

✅ Summary

Semax is a multi-modal neuropeptide with compelling nootropic, neuroprotective, and neurorestorative effects. It operates via robust molecular pathways—BDNF upregulation, monoamine enhancement, antioxidant activity, and gene-level modulation—demonstrated in both preclinical and early clinical settings. As foundational research continues, Semax is well-positioned to evolve into a powerful tool in brain health, cognitive support, and post-ischemic care.

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The products offered on this website are furnished for in-vitro studies only. In-vitro studies(Latin: in glass) are performed outside of the body. These products are not medicines or drugs and have not been approved by the FDA to prevent, treat or cure any medical condition, ailment or disease. Bodily introduction of any kind into humans or animals is strictly forbidden by law.