Thymalin 10mg

1. What is Thymalin?

Thymalin is a polypeptide complex originally derived from the thymus of calves and used for its immunomodulatory and regenerative properties. It was developed in Russia in the 1970s and has been studied for its ability to normalize immune function, regulate hematopoiesis, and promote tissue regeneration. Thymalin acts by influencing gene expression related to cell differentiation, apoptosis, and immune system balance.

2. Thymalin Structure

Molecular Formula：C33H54N12O15

Molecular Weight：858.86g/mol

CAS Number：63958-90-7

3. Thymalin Research

Thymalin is a natural polypeptide complex derived from calf thymus, enriched with bioactive fragments such as EW dipeptide (Thymogen), KE, and EDP, all under 10 amino acids, which regulate immune, regenerative, and aging-related pathways.

【1】 Molecular & Cellular Mechanisms

Immune cell modulation: Enhances differentiation and proliferation of T/B lymphocytes, boosts phagocytosis, and reverses apoptosis in immune cells 【https://pmc.ncbi.nlm.nih.gov/articles/PMC8365293/?utm_source=chatgpt.com】.

Cytokine balancing & anti-inflammation: Attenuates hyperinflammatory cytokines (IL-6, TNFα), upregulates IFNγ/IL2, highstress response proteins (Hsp70/90), and maintains NFκB/p38 signaling for homeostasis .

Lymphoid & hematopoietic support: Restores thymic output and hematopoiesis post-chemotherapy or irradiation, rebalances CD4⁺ T-cell subsets, and supports bone marrow regeneration 【https://pmc.ncbi.nlm.nih.gov/articles/PMC8365293/?utm_source=chatgpt.com】.

Respiratory epithelium & ciliary function: Supports mucociliary clearance by preserving ciliary beat frequency and epithelial health amid inflammatory stress .

【2】 Preclinical & Clinical Data

Immune restoration in elderly: Reverses agerelated thymic involution and boosts infection resistance in seniors; reduces acute respiratory infections 2–2.4× 【https://pmc.ncbi.nlm.nih.gov/articles/PMC8365293/?utm_source=chatgpt.com】.

Viral/bacterial infection support: Proven adjunct therapy in pneumonia, hepatitis B/C, HIV, sepsis, and COVID19; quick resolution of cytopenia and coagulopathy in hospitalized cases【https://clinmedjournals.org/articles/ijii/international-journal-of-immunology-and-immunotherapy-ijii-7-055.php?utm_source=chatgpt.com】.

Post-op & chemo recovery: Enhances postoperative immune markers and shortens complications in elderly surgical patients 【https://pmc.ncbi.nlm.nih.gov/articles/PMC8654498/?utm_source=chatgpt.com】.

Neuro-inflammatory protection: Thymulin (a component) inhibits microglial activation to reduce neuropathic pain and neuroinflammation 【https://www.sciencedirect.com/science/article/abs/pii/S1567576918304387?utm_source=chatgpt.com】.

Nanoparticle enhancement: Improved anticytokine storm effect in preclinical sepsis models using thymalin-nanoparticle complexes .

✅ Why Consider Thymalin?

🧬 Superior immunocorrection: Effectively restores immune functionality and lymphocyte balance.

⚖️ Inflammation control: Naturally regulates cytokine storms and protects tissues via NFκB modulation.

🌱 Regenerative support: Promotes thymic output, bone marrow health, and epithelial repair.

💪 Geroprotective benefits: Mitigates age-related immune decline and improves resilience.

🌍 Effective in real-world illness: Used successfully during COVID-19, sepsis, pneumonia, and viral hepatitis.

🔬 Component synergy: Dipeptide/tripeptide fragments are active biologically, enhancing potency.

🧠 Neuro-inflammatory aid: Potential in pain management and CNS protection via microglial modulation.

🌐 Cutting-edge delivery research: Advanced nanoparticle forms for optimized delivery in inflammatory conditions.

4. Future Thymalin Research

• Expanded immunology trials
  Large-scale RCTs in elderly, chronic infections, autoimmunity, and post-chemotherapy immunosuppressed conditions.
• Neuroinflammation & neuroprotection
  Clinical evaluation in neurodegenerative and neuropathic pain disorders, focusing on microglia-driven inflammation.
• Targeted delivery systems
  Development of nanoparticle or liposomal thymalin delivery for respiratory, CNS, or systemic inflammatory management.
• Biomarker profiling
  Gene and protein expression analyses to clarify pathways (Hsp, cytokines, NFκB) and identify optimal therapeutic windows.
• Peptide synergy protocols
  Combined studies with epitalon, BPC157, or NAD⁺ boosters to evaluate multi-peptide anti-aging and immunity-enhancing regimens.
• Cognitive and recovery metrics
  Measurable outcomes in physical recovery, fatigue reduction, and cognition post-illness or surgery.

5. Application Areas

✅ Summary

Thymalin is a venerable yet advanced thymic-derived peptide complex with broad therapeutic promise in immunomodulation, inflammation control, regeneration, and anti-aging applications. Supported by decades of clinical and preclinical evidence—and backed by fragment peptides like Thymogen—it offers multi-layered immune support tailored for aging, recovery, and systemic resilience. Emerging delivery technologies and new trials are set to expand its role in modern wellness and clinical peptide formulations.

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The products offered on this website are furnished for in-vitro studies only. In-vitro studies(Latin: in glass) are performed outside of the body. These products are not medicines or drugs and have not been approved by the FDA to prevent, treat or cure any medical condition, ailment or disease. Bodily introduction of any kind into humans or animals is strictly forbidden by law.