Thymosin Alpha-1 5mg

1. What is Thymosin Alpha-1?

Thymosin Alpha-1 (Tα1) is a naturally occurring peptide fragment consisting of 28 amino acids, originally isolated from the thymus gland. It is known for its powerful immunomodulatory and antiviral properties. Thymosin Alpha-1 plays a central role in the maturation and activation of T-cells and is widely studied for its use in immune dysfunction, chronic infections, cancer immunotherapy, and vaccine response enhancement.

2. Thymosin Alpha-1 Structure

【pictures linking，https://pubchem.ncbi.nlm.nih.gov/compound/16130571】

Sequence:Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-lle-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn

Molecular Formula: C129H215N33O55

Molecular Weight: 3108.315 g/mol

PubChem ClD:16130571

CAS Number: 62304-98-7

Synonyms: Thymalfasin

3. Thymosin Alpha-1 Research

Thymosin Alpha1 (28 amino acids, AcSerAspAla…AsnOH) is a natural thymus-derived peptide with powerful immune-regulating functions. Its synthetic form, Thymalfasin, is widely used, especially in over 35 countries, for boosting immunity in hepatitis, cancer, vaccine response, sepsis, and viral illnesses, including COVID19 【https://pmc.ncbi.nlm.nih.gov/articles/PMC7747025/?utm_source=chatgpt.com】.

【1】 Molecular & Cellular Mechanisms

T lymphocyte maturation: Enhances CD4⁺ and CD8⁺ T-cell activation and boosts NK and dendritic cell function ([turn0search0], [turn0search1], [turn0search19]).

TLRmediated immunomodulation: Agonizes TLR2 and TLR9 on antigen-presenting cells—heightening adaptive immunity 【https://en.wikipedia.org/wiki/Thymosin_%CE%B11?utm_source=chatgpt.com】.

Cytokine regulation: Elevates IL2, IFNγ, IL10, IL12 while dampening IL6/TNF-α—optimizing inflammation balance 【https://pmc.ncbi.nlm.nih.gov/articles/PMC7747025/?utm_source=chatgpt.com】.

Anti-proliferative & antioxidant: Inhibits tumor growth in certain cancers and boosts antioxidant enzymes (SOD, catalase, glutathioneperoxidase) 【https://www.wjgnet.com/2220-3249/full/v9/i5/67.htm?utm_source=chatgpt.com】.

Direct antiviral response: Promotes antigen presentation, reduces viral replication, and reverses lymphopenia in SARS-CoV2 【https://pmc.ncbi.nlm.nih.gov/articles/PMC7747025/?utm_source=chatgpt.com】.

【2】 Clinical & Real-world Evidence

Hepatitis B & C: Approved for HBV in over 35 countries; combined with antivirals shows >40% viral clearance in chronic HBV 【https://pmc.ncbi.nlm.nih.gov/articles/PMC7747025/?utm_source=chatgpt.com】.

Cancer synergy: Enhances vaccine and checkpoint-inhibitor responses in melanoma, NSCLC, HCC, and others 【https://www.fda.gov/media/183892/download?utm_source=chatgpt.com】.

Sepsis & critical illness: Reduces mortality in sepsis and improves survival in COVID19 ICU cases【https://pmc.ncbi.nlm.nih.gov/articles/PMC7747025/?utm_source=chatgpt.com】.

Vaccine adjuvant: Raises seroconversion in influenza and hepatitis B vaccines in elderly/immunocompromised.

COVID-19 response: In Hubei cohort studies, TA1 raised T-cell counts and correlated with better survival.

HIV support: Improves CD4 recovery and reduces viral load when combined with ART【https://www.fda.gov/media/183892/download?utm_source=chatgpt.com】.

✅ Why Consider Thymosin Alpha1?

🧬 Holistic immune restoration: Boosts T-cell, dendritic cell, and NK-cell activity for robust immunity.

⚖ Balanced inflammation: Fine-tunes both pro- and anti-inflammatory cytokine signals.

🌍 Broad antiviral & anticancer support: Enhances responses across hepatitis, HIV, sepsis, melanoma, etc.

💉 Vaccine enhancement: Maximizes efficacy in vulnerable populations.

🏥 Synergy with therapies: Proven efficacy alongside immunotherapies, antivirals, and vaccines.

🚀 Real-world success: Used globally in hospitals for infections and immune-compromised patients.

🔬 Pharmaceutical-grade synthesis: Produced via solid-phase or recombinant methods ensuring consistency 【https://pmc.ncbi.nlm.nih.gov/articles/PMC7115394/?utm_source=chatgpt.com】.

4. Future Thymosin Alpha-1 Research

Expanded antiviral trials
Controlled RCTs in COVID19, long COVID, novel respiratory pathogens, and viral co-infections.

Oncology combinations
Clinical studies with checkpoint inhibitors/tyrosine kinase inhibitors in melanoma, HCC, lung cancer, etc. .

Aging and immunosenescence
Investigating benefits for elderly patients, vaccine unresponsiveness, and frailty .

Sepsis, ARDS, cytokine storm
Rigorous trials to confirm reduced mortality and hospital stay in critical infections .

Dose optimization & delivery
Developing depot formulations, oral/nasal options, and combination delivery with vaccines or peptides.

Biomarker-based personalization
Tailoring treatment using T-cell counts, cytokine levels, and antigen presentation markers.

5. Application Areas

✅ Summary

Thymosin Alpha1 is a clinically validated immune-restorative peptide with decades of use in chronic viral illness, cancer, vaccine enhancement, and critical care. By stimulating both innate and adaptive immunity—while balancing inflammation—it offers versatile benefits across infection prevention, treatment adjuncts, and immunosenescence. Ongoing research seeks to expand its impact in oncology, aging, and critical care therapeutics, making it a valuable asset for wellness and health support programs.

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The products offered on this website are furnished for in-vitro studies only. In-vitro studies(Latin: in glass) are performed outside of the body. These products are not medicines or drugs and have not been approved by the FDA to prevent, treat or cure any medical condition, ailment or disease. Bodily introduction of any kind into humans or animals is strictly forbidden by law.